The role of mean systemic filling pressure and incubator tilt induced etCO2 change for the prediction of fluid responsiveness in neonates - a feasibility study

The role of mean systemic filling pressure and incubator tilt induced etCO2 change for the prediction of fluid responsiveness in neonates - a feasibility study - Prediction of fluid responsiveness in neonates

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38430

Enrollment

Registered

2013-09-13

Start date

2013-09-02

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovolemia low volume

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: • Arterial catheter in place, well functioning with the tip positioned in the radial artery or posterior tibial artery (for Pmsf measurement) • Mechanical ventilation with capnography (for ΔetCO2 assessment) • Informed consent obtained from parents or representatives • Steady state as judged by the attending physician

Exclusion criteria

Exclusion criteria: • Life-threatening congenital defects • Perinatal asphyxia • Intraventricular hemorrhage > grade 1 • Central venous catheter of peripheral infusion with administration of (cardiovascular) drugs, that can not be interrupted secondary to vascular occlusion for 30 seconds • Condition in which an incubator tilt is contraindicated, such as for example external ventricular drainage;• Condition in which any handling is contraindicated

Design outcomes

Primary

Measure	Time frame
The two study parameters are • The mean systemic filling pressure (Pmsf), assessed with an extremity occlusion test • The change in end-tidal carbon dioxide pressure (ΔetCO2) in response to a incubator tilting maneuver	—

Countries

Netherlands

Outcome results