PET imaging of neuroinflammation in mild traumatic brain injury

PET imaging of neuroinflammation in mild traumatic brain injury - Neuroinflammation in mTBI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38412

Enrollment

Registered

2012-07-24

Start date

2013-03-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild traumatic brain injury neurological disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All subjects: -Age above 18 and below 50 years. -Written informed consent for participation.;Patients only: -Diagnosis of mild traumatic brain injury. -No abnormalities in the structural MRI during neurologist follow-up, 4-6 weeks after the injury.

Exclusion criteria

Exclusion criteria: All subjects: -The use of benzodiazepines. -The use of anticoagulants or having coagulation disorder. -Use of somatic medication that may affect the immune system. -Use of any investigational drug. -Current or recent (

Design outcomes

Primary

Measure	Time frame
The [11C]-PK11195 binding potential in the brain, and the performance in the neuropsychological tests will be the primary parameters.	—

Secondary

Measure	Time frame
Secondary study parameters are white matter integrity, MRI Spectroscopy and serum proteins indicative of inflammation.	—

Countries

Netherlands

Outcome results