microvascular insulin resistance
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-55 years 2. BMI
Exclusion criteria
Exclusion criteria: 1. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure, cardiac shunts, heart valve replacement, pulmonary hypertension). 2. Pulmonary disease. 3. Diabetes mellitus (FPG > 7.8 mmol/L). 4. Smoking. 5. Hypertension (>140/90 mmHg). 6. Alcohol use > 4 U/day. 7. Use of medication (antihypertensive medication, statins, corticosteroids, NSAIDs, ciclosporin A, rifampicin). 8. Pregnancy or lactation. 9. Insufficient knowledge of the Dutch language. 10. Known allergic reaction to ultrasound contrast-agent. 11. Known cardiac dysrhythmias (e.g. atrial fibrillation, long QT-syndrome) or a family history of cardiac dysrhythmias or sudden cardiac death.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Inter-observer variability in offline analysis of CEUS measurements. 2. Skeletal muscle microvascular flow distribution. 3. Change in skeletal muscle microvascular flow distribution from baseline to post-exercise status. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Intra-observer variability and day-to-day variation of forearm skeletal muscle CEUS measurements. 2. The percentage change in microvascular blood volume (MBV), flow and flow velocity (MFV), measured by means of CEUS signal, in forearm skeletal muscle from baseline to post-exercise status. | — |
Countries
Netherlands
Outcome results
None listed