Alzheimer disease frontotemporal dementia
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Families with (probable) autosomal dominant inheritance of frontotemporal dementia, dementia with Lewy bodies or early onset Alzheimer dementia. - Families fitting autosomal dominant inheritance: o Frontotemporal dementia or dementia with Lewy bodies in at least three persons in two consecutive generations, or o Alzheimer dementia in at least three persons in two consecutive generations all with an onset below the age of 65 years. - Families suggestive of autosomal dominant inheritance: o Frontotemporal dementia or dementia with Lewy bodies in at least two persons, or o Alzheimer dementia in at least three persons, 1st or 2nd degree related to each other, of whom at least one has an onset below the age of 65 years, or o Alzheimer dementia in at least two persons, 1st or 2nd degree related to each other, with both an onset below the age of 65 years.;2. A sufficient understanding of the Dutch language and cognitive abilities to understand questions and procedures of participants or their (legal) representatives
Exclusion criteria
Exclusion criteria: * Families in which a causal mutation has been identified * Families that are known to be unwilling to participate in research * Families in which no DNA of any affected person is or will be available
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| identifying genes causing frontotemporal dementia, dementia with Lewy bodies and early onset Alzheimer dementia | — |
Countries
Netherlands
Outcome results
None listed