"have the blues" mood disorder
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: PATIENTS Between 18 - 70 years old and able to give voluntary informed consent Diagnosis of unipolar depression. The diagnosis of depression will be made by the participants* treating psychiatrist/ psychologist and confirmed with the Structured Clinical Interview for DSM-IV (SCID-I). Severity of the depression: moderate to severe (BDI-II score >=20) Duration of the depression: longer than 2 months Are already receiving or will receive in the coming weeks treatment for depression;HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION Between 18 - 70 years old No current or history of major psychiatric illness A first-degree relative (i.e. father, mother, brother or sister) that has been diagnosed with unipolar depression. This diagnosis needs to be confirmed by the GP, psychologist or psychiatrist of the family member;HEALTHY CONTROLS Between 18 - 70 years old No current or history of major psychiatric illness No family history of major depression
Exclusion criteria
Exclusion criteria: PATIENTS Meeting DSM-IV criteria for schizophrenia, schizo-affective disorder, bipolar disorder or an anxiety disorder as a primary diagnosis Meeting DSM-IV criteria for drug dependence as a primary diagnosis High suicidal risk (evaluated by the treating clinicians as part of standard therapy procedures) MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding Serious medical or neurological illness Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding Serious medical or neurological illness Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam HEALTHY CONTROLS Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding. Serious medical or neurological illness Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in structural T1, DTI, functional resting-state and functional task-related connectivity and effective connectivity between: 1)depressed patients and healthy controls 2)depressed patients and healthy participants with a genetic vulnerability to depression 3)healthy controls and healthy participants with a genetic vulnerability to depression 4)depressed patients before and after 9 months of treatment Correlations between: 1)severity of depression and functional/anatomical connectivity 2)cognitive performance and functional/anatomical connectivity 3)treatment success and changes in functional/anatomical connectivity | — |
Countries
Netherlands
Outcome results
None listed