epilepsy seizures
Conditions
Interventions
TMS (transcranial magnetic stimulation).
The TMS equipment has a maximum output of 1.5 Tesla. The puls duration is 400
microsec. Pulses are given with a frequency of ~0.25 Hz (single pulse TMS).
F
Sponsors
Universiteit Twente
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age between 18 and 60;patients: focal epilepsy
Exclusion criteria
Exclusion criteria: hearing problems (possible) pregnancy metal objects in brain/skull cochleair implang, implanted brain electrode or pacemaker severe medical condition take medications that lower the threshold for seizure spinal surgery, drains in spinal cord or ventricles use illegal drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main endpoints are the presence and characteristics of the auditory evoked potential, the TMS-MEP and TMS-EEG response. Auditory evoked potential o Amplitude (microV) o Latency (msec) MEP o Amplitude (mV) o Latency (msec) o Motor Threshold (Tesla) TMS-EEG response o Amplitude of peaks (microV) o Latencies of peaks (msec) | — |
Secondary
| Measure | Time frame |
|---|---|
| TMS-EEG response: Additional signal analysis methods, including wavelet analysis of early and late TMS-EEG responses and the spatiotemporal characteristics of the TMS-EEG response. In the epilepsy patients, we will record the number of epileptic abnormalities in the EEG before and after the TMS experiment. | — |
Countries
Netherlands
Outcome results
None listed