breast cancer breast neoplasm
Conditions
Interventions
During the run-in period, all women will follow a weight maintenance diet
according to guidelines for healthy nutrition (50-60% carbohydrate,
15-20%protein and 20-35% fat) under supervision of a die
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Female. 50-69 years of age. Postmenopausal (>12 months after last menses). BMI 25-35 kg/m2. Inactive (4 MET)). Willing to be randomly assigned to one of the three study arms.
Exclusion criteria
Exclusion criteria: Use of sex hormones in the past 12 months. Suffering from breastcancer (in medical history) or other cancers in the last 5 years, except for non-melanoma skin cancers. Suffering from type II diabetes mellitus or other endocrine related diseases. Smoker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sex-hormone levels: estradiol, estrone, testosterone, sex hormone binding globulin (SHBG). | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical fitness, anthropometrics, the amount of total body fat (DEXA scan) and abdominal fat (MRI). We also measure lifestyle factors: i.e. habitual physical activity, dietary pattern, alcohol consumption and medication use. | — |
Countries
Netherlands
Outcome results
None listed