geen aandoening not applicable
Conditions
Interventions
Participants will be treated with methylphenidate, levodopa/carbidopa or
placebo. All medications will be administered orally with a capsule. The
treatment order will be established by counterbalanc
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male or female • 18 to 45 years of age • Healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected), • Body mass index between 18.5 and 30 • Willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: - history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness. - having suffered from depression, bipolar disorder, anxiety disorder, panic disorder, psychosis, or attention deficit hyperactivity disorder - those volunteers who have a first-degree relative with a psychiatric disorder or a history with a psychiatric disorder - excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoints are the Contingent Negative Variation (CNV) amplitude in the electroencephalogram (EEG) and the response time on the Response preparation (Lines and Stoplight) tasks. For memory functions: total number of words recalled at immediate recall in word learning test (WLT); number of words recalled in WLT at delay of 30 min and 24h; accuracy and reaction time recognition test of WLT, heart rate, prolactine levels in blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are performance on a Sternberg memory scanning task, Object relocation, Set shifting, paired associates learning test; Visual analogue scales: Profile of moods states (POMS) and Bond & Lader (B&L); Resting EEG. | — |
Countries
Netherlands
Outcome results
None listed