cystic fibrosis
Conditions
Interventions
Included participants subsequently undergo:
- 6 weeks of standardised (sham) IMT with an inspiratory threshold-loading
device (Threshold IMT, PT Medical, Leek, The Netherlands). Progression of
inten
5 BX). Frequency is 5 days a week, 11 minutes a day.
Patients are instructed at follow-up points and controlled by e-mail and
telephone by one of the physiotherapists from the WKZ (H.J. Hulzebos).
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: •Ambulant patients with CF •Age: range from 12 to 18 years of age
Exclusion criteria
Exclusion criteria: - Acute gastro-intestinal or pulmonary exacerbation (extra oral or intravenous antibiotics for the past four weeks) at inclusion. - Oxygen saturation (SpO2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The peak work rate in watts (Wpeak) achieved during the aerobic maximal exercise test (CPET). The main study parameter of the alternative protocol is the * time recovery of phosphocreatine (1/2 time PCr recovery) after maximal exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| - work of breathing in rest and during exercise - exercise capacity (except Wpeak) - disease specific and generic Health Related Quality of Life - habitual daily activity - respiratory muscle function - peripheral muscle function - rate of perceived exertion - patient specific goals - co morbidity - spirometry - anthropometry - use of medication and other care - compliance to interventions - feasibility of interventions and measurements - type of CF gene mutation | — |
Countries
Netherlands
Outcome results
None listed