het gaat hier om gezonde vrijwilligers zonder aandoening. chemoresistance
Conditions
Interventions
The intervention is this study is intake of fish or fish oil at T0.
Volunteers will be randomly assigned to one of three fish oil brands, or to
each of the fish species.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. The volunteer must be >= 18 years of age 2. The volunteer must be healthy, meaning: * no history of diabetes mellitus * no history of immune disorders * no history of hypercholesterolemia * no use of anti-coagulant medication * no breast feeding * no allergy to fish or related products 3. The patient may not have used fish oil products within 2 weeks before start of the study 4. The patient may not have eaten a fish meal within 1 week before the start of the study 5. The patient must have given written informed consent
Exclusion criteria
Exclusion criteria: Any other condition by which the volunteer does not meet the inclusion criteria.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint: The ability of plasma withdrawn from volunteers that have ingested fish oil or fish to induce resistance in an in vitro tumor cell culture, or in vivo in mouse models. | — |
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint: To determine the level of 16:4(n-3) in plasma withdrawn from volunteers that have ingested fish oil or fish. | — |
Countries
Netherlands
Outcome results
None listed