Epilepsy falling sickness
Conditions
Interventions
None listed
Sponsors
Epilepsiecentrum Kempenhaeghe
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The study will be divided into two phases related to two distinct patient groups, as described below. 1. proof-of-concept study for the methodological development (n
Exclusion criteria
Exclusion criteria: - suspicion of psychogenic non-epileptogenic seizures; - suspicion of other neurological disorders; - patients who cannot meet the mild physical or psychological criteria for prolonged MRI scanning; - patients with very severe tonic-clonic seizures. - patients who have a pacemaker or intracranial metals. These exclusion criteria will be based on available clinical information of the patient and will be discussed with the neurologist of the patient. If the neurologist thinks that a patient will not be capable to participate in the study, the patient will not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the similarity of the epileptic network(s) obtained by the standard EEG-fMRI procedure and the data driven approach. The gold standard used for validation are the results of the electroclinical examination of the patient including the result of the EEG-Video examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary study parameter is the confirmation or rejection of the null-hypothesis of this study that the epileptiform network is similar before and after medication withdrawal. In that case the data-driven approach might be a valuable additional tool in the pre-operative work-up of patients with localization related epilepsy, because it yields information that is not dependent on EEG and the possible changes in (the amount of) epileptic activity of the EEG. | — |
Countries
Netherlands
Outcome results
None listed