a low concentration of the protective ('good') cholesterol Low HDL cholesterol
Conditions
Interventions
During the experimental period, subjects will receive one capsule at lunch and
one at dinner daily. Each capsule will provide 75 mg resveratrol. During the
control period, subjects will receive two
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • aged between 45 and 70 years • HDL-C
Exclusion criteria
Exclusion criteria: • unstable body weight (weight gain or loss >3 kg in the past 3 months) • indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus • use of medication or a medically-prescribed diet known to affect serum lipid or glucose metabolism. Oral anti-contraceptives and paracetamol are allowed. • Active cardiovascular disease (for instance congestive heart failure) or recent (21 glasses of alcohol-containing drinks per week women: consumption of >14 glasses of alcohol-containing drinks per week • abuse of drugs • pregnant or breastfeeding women • participation in another biomedical study within 1 month prior to the screening visit • having donated blood (as blood donor) within 1 month prior to the screening visit or planning to do so during the study • impossible or difficult to puncture as evidenced during the screening visits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the change in serum apoA-I concentrations and serum HDL-C. | — |
Secondary
| Measure | Time frame |
|---|---|
| -flow-mediated dilation -pulse wave velocity -glucose- en insulineconcentration -ApoB -Total cholesterol -LDL-C -Triglycerides -hdCRP -IL-6 -sICAM-1 -VCAM-1 -MCP-1 -sE Selectin - Blood chemistry: phosphorus, sodium, potassium, chloride, calcium, creatinine, blood urea nitrogen (BUN), protein, albumin, gammaGT, aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin - Haematology: White cell count, red cell count, platelet count, hemoglobin, hematocrit, mean cell volume, and mean cell hemoglobin concentration, red cell distribution - Blood coagulation: Prothrombin time (PT) and aPT | — |
Countries
Netherlands
Outcome results
None listed