A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition

A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition - LPS-pilot healthy volunteers/patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38316

Enrollment

250

Registered

2008-04-22

Start date

2008-09-17

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerose rheumatoid arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy males healthy female volunteers: pre- and post-menopausal patients with rheumatoid arthritis: active disease and with or without treatment with MTX patients with Crohn's disease: clinically confirmed diagnosis of disease patients with psoriasis: clinically confirmed diagnosis of disease, PASI score>5 patients with asthma: clinically confirmed diagnosis of disease patients with proven atherosclerotic disease

Exclusion criteria

Exclusion criteria: general: any clinically significant disorder (current or past medical history or physical examination) that in the opinion of the investigator precludes study participation patients: clinically significant abnormalities and recent treatment with anti-TNF therapy

Design outcomes

Primary

Measure	Time frame
activation markers of inflammation (cytokines, chemokines, etc)	—

Countries

Netherlands

Outcome results