Uremic Toxin Removal and Hemodynamics in Long-Hour Hemodialysis and Hemodiafiltration; A Randomized Cross-Over Study

Uremic Toxin Removal and Hemodynamics in Long-Hour Hemodialysis and Hemodiafiltration; A Randomized Cross-Over Study - Acute effects of long-hour dialysis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON38305

Enrollment

Registered

2011-04-11

Start date

2011-10-10

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

end-stage renal disease

Interventions

Prevalent conventional hemodialysis patients will undergo a conventional hemodialysis session to study the baseline kinetics and hemodynamics and will subsequently undergo, in a random way, a 4-hour

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -prevalent stable CHD patients with insignificant residual urine production -AV-fistula enabling double-needle vascular access with blood flow rate of at least 350 ml/min -informed consent -age more than 18 years

Exclusion criteria

Exclusion criteria: -withdrawal of consent -acute intercurrent illness (infection, malignancy, cardiovascular event, uncontrolled diabetes)

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is the removal of (especially protein-bound) uremic toxins.	—

Secondary

Measure	Time frame
Microcirculation measured by capillaroscopy	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)