bipolar disorder manic depressive disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with bipolar disorder - A diagnosis of BD-I according to the DSM IV, with at least one clinical intervention for mania (DSM-IV criteria) - No history of Cognitive Disorder (DSM-IV criteria) - Age >= 18 years - Dutch ancestry (at least three of the four grandparents from the Netherlands);Healthy controls - Age >= 18 years - Dutch ancestry (at least three of the four grandparents from the Netherlands) - No history of bipolar disorder, schizophrenia or other psychotic disorder (DSM-IV criteria) - No first degree relative with a history of bipolar disorder, schizophrenia or other psychotic disorders (DSM-IV criteria), on the basis of a FIGS interview
Exclusion criteria
Exclusion criteria: - Premorbid IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main studyparameter is structural abnormalities in the brain of bipolar patients, compared to unrelated healthy controls. These structural differences will be measured by; - Brain volume (sMRI) and density (voxelbased morphometry) - Fractional anisotropy and magnetisation transfer ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameter is data that associates the structural data with genetic data. Furthermore, we will also study baseline values or parameters which might intervene with the main study parameter, like age, gender, years of education, symptoms, level of functioning, medication intake and life events. We are mainly interested in the effect op medication on the bipolar brain. | — |
Countries
Netherlands
Outcome results
None listed