Calcium Role in the Excitation-Contraction and Excitation-Transcription Coupling Processes in Human Atrial Fibrillation.

Calcium Role in the Excitation-Contraction and Excitation-Transcription Coupling Processes in Human Atrial Fibrillation. - Excitation-Contraction and Excitation-Transcription Coupling in AF.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38277

Enrollment

570

Registered

2010-06-15

Start date

2011-03-14

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial arrhythmia. Atrial fibrillation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients in sinus rythm and undergoing for openchest surgery. Male and female patients over 18 years old. Patients with paroxysmal AF and undergoing for openchest surgery. Patients with persistent AF and undergoing for openchest surgery. Patients who have given written consent.

Exclusion criteria

Exclusion criteria: Patients who are scheduled for re-operation. Male and female patients under 18 years old. Patients who do not speak/understand Dutch. Patients who are not will-competent.

Design outcomes

Primary

Measure	Time frame
Main study parameters/endpoints: 1/. To identify new cellular proarrhythmic mechanisms. 2/. To identify new nuclear targets for therapy (i.e. important factors involved in Ca2+-dependent transcription pathways).	—

Secondary

Measure	Time frame
The knowledge of the cellular mechanisms activated during persistent AF will significantly enhance the chances of better treatment to not only cardioconvert AF, but also to allow the atrial cells to recuperate their function after AF. This is expected to reduce the thromboembolic risks and improve cardiac function after cardioversion of AF.	—

Countries

Netherlands

Outcome results