Systemisch: thermoregulatie Exertional hyperthermia overheating during exercise
Conditions
Interventions
Subjects will all perform submaximal treadmill exercise. Before every exercise
test, one of the following interventions will be applied in random order 45
minutes prior to the start of exercise:
A:
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18 years - Willing to participate in all parts of the present study, and willing to confirm this by signing an informed consent. - Trained in running (performs running exercise 1.5 hours/week on average)
Exclusion criteria
Exclusion criteria: - A history of any hypersensitivity reactions or idiosyncratic reactions in response to paracetamol (acetaminophen) or ibuprofen. - A history of or ongoing obstructive/inflammatory bowel disease or surgery to the gastro-intestinal tract (not contraindicated: appendectomy or cholecystectomy). - The presence of an implanted electric (medical) device, such as an ICD or pacemaker. - Expected to undergo an MRI scan within 5 days after one of the submaximal exercise tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Core body temperature. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Skin Temperature - Interleukin-1* - Interleukin-6 - Heart rate - Body Weight - Rating of Perceived Exertion (BORG-score) - Thermal Comfort score - Thermal sensation score | — |
Countries
Netherlands
Outcome results
None listed