Obesitas nvt
Conditions
Interventions
Each individual will undergo three experiments with a different intervention.
During the first experiment, the individual will receive a liquid meal
containing 60% of their daily required energy int
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Healthy lean and obese adults • Age 18-30 years • Gender: Male • Lean: BMI 18.5-25 kg/m2;Obese: BMI >= 30 kg/m2 • Caucasians
Exclusion criteria
Exclusion criteria: • Diabetes Mellitus • Hyperthyroidism • Cardiovascular and renal diseases • Tachy-arrhythmias • Asthma and other obstructive pulmonary diseases • Hypertension (systolic/diastolic blood pressure >140/90) • Hypotension (systolic/diastolic blood pressure 5.6 mmol/L) • Medication: use of ß-blockers, tricylic antidepressants, MAO inhibitors • Glaucoom: use of the medicine betamimeticum • Individuen die al eerder mee hebben gedaan aan bruin vet onderzoek met een PET-CT scan of al een keer medische bestraling hebben gehad • Jicht • Lever insufficiëntie
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Standard uptake value*s (SUV*s) of brown adipose tissue - Skeletal muscle mitochondrial respiration/uncoupling - Energy expenditure | — |
Secondary
| Measure | Time frame |
|---|---|
| - Body temperatures - Skin perfusion - Body composition - Blood parameters - UCP-1 and beta3-receptor polymorphisms | — |
Countries
Netherlands
Outcome results
None listed