Assessment of asymmetrical innervation of the right and left m. puborectalis as a possible cause of idiopathic incontinence, by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles.

Assessment of asymmetrical innervation of the right and left m. puborectalis as a possible cause of idiopathic incontinence, by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles. - An asymmetrical innervated sphincter is insufficient.

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38239

Enrollment

Registered

2012-06-15

Start date

2012-08-30

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denervation loss of nerve supply

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: The subjects have idiopathic urinary or faecal incontinence problems. The subjects have an overactive bladder or dysfunctionel voiding. The subjects are in the age of 5 to 17 years. The subjects need a cystoscopy.

Exclusion criteria

Exclusion criteria: When subjects have had bladder neck surgery. When subjects have severe congenital anomalies of bladder neck and urethra (epispadias, ectopic ureteroceles, exstrofy).

Design outcomes

Primary

Measure	Time frame
There will be tonic activity in the puborectalis muscle when the patient is sedated (low-threshold MUPs), in contrast to skeletal muscles. A difference in muscle activity is demonstrated by the motor unit potential (MUP) count. Besides that there is a prolonged insertion activity in denervated muscles.	—

Secondary

Measure	Time frame
The MUP parameters will be compared with the normative values as described in literature. MUP parameters are: amplitude, duration, area, thickness, size index, phases, turns and spike duration. In denervated and reinnervated muscles these values are abnormal. In reinnervated muscles a prolonged wave form of the MUP is seen together with instability of the MUP. After some time the duration of the MUP reverts towards normal while the MUP amplitude increases. Furthermore, it is important to observe whether there is abnormal spontaneous activity on one or both muscles, because this is an indication for a pathology.	—

Measure

Time frame

The MUP parameters will be compared with the normative values as described in literature. MUP parameters are: amplitude, duration, area, thickness, size index, phases, turns and spike duration. In denervated and reinnervated muscles these values are abnormal. In reinnervated muscles a prolonged wave form of the MUP is seen together with instability of the MUP. After some time the duration of the MUP reverts towards normal while the MUP amplitude increases. Furthermore, it is important to observe whether there is abnormal spontaneous activity on one or both muscles, because this is an indication for a pathology.

—

Countries

Netherlands

Outcome results