recurrent implantation failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All groups: - age from 18 till 38 years at moment of IVF or ICSI treatment - regular mentrual cycle ( 25-35 days);Study group: Women who have not achieved a pregnancy, despite at least three fresh embryo transfers in an IVF or ICSI treatment. - An abortion will be regarded as a pregnancy. - A chemical pregnancy will not be regarded as a pregnancy.;Control group Women who conceived after the first or second ICSI treatment for male factor infertility and who have delivered a healthy baby.;Reference group Women who conceived and have delivered a healthy baby within three IVF attempts.
Exclusion criteria
Exclusion criteria: All groups: - Use of oral anticonceptives or an intra-uterine device - Difficulty in communicating in Dutch or English - Poor ovarian response after adequate ovarian stimulation - Smoking;Study group - PESA (percutaneous epididymal sperm aspiration) / MESA (microsurgical epididymal sperm aspiration / TESE (testicular sperm extraction) - Abortion following the IVF or ICSI treatment - A known cause of recurrent implantation failure detected during pre-inclusion screening. - Poor embryo quality;Control group - Other causes of infertility than severe male infertility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Validation of our initial findings of a molecular signature which can be distinguish between normally receptive and less-receptive endometrium (06/101/K) | — |
Secondary
| Measure | Time frame |
|---|---|
| - To identify differences between normally receptive and less-receptive endometrium by protein expression. - To implement our findings of the molecular signature in the IVF patient population. Comparing gene expression results betweeen IVF patients that conceived within 3 IVF attempts and patients who didn't ( implantation failure). | — |
Countries
Netherlands
Outcome results
None listed