Intracranial aneurysms: searching for markers of instability and risk of rupture

Intracranial aneurysms: searching for markers of instability and risk of rupture - Risk of rupture markers in intracranial aneurysms

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38220

Enrollment

210

Registered

2011-01-10

Start date

2011-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial aneurysms

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients of age 18 years or older with a ruptured or unruptured intracranial aneurysm who need surgical clipping (N=70) or endovascular coiling (N=70) to treat the aneurysm.;For the control group: patients of age 16 years or older with therapy resistant epilepsy who need epilepsy surgery with brain resection (N=70).

Exclusion criteria

Exclusion criteria: Patients with a ruptured or unruptured intracranial aneurysm who will not undergo treatment of the aneurysm or who are under the age of 18 years.;For the control group: Patients with therapy resistant epilepsy who need epilepsy surgery with brain resection who are under the age of 16 years or who have an intracranial aneurysm or other vascular malformation.

Design outcomes

Primary

Measure	Time frame
1. differences in gene expression of ruptured and unruptured aneurysmal biopsies and control tissue 2. changes in cell types or vessel wall components of ruptured and unruptured aneurysmal biopsies and control tissue 3. correlation of the expression of proteins of interest with the size/stage of development of the aneurysm.	—

Countries

Netherlands

Outcome results