impaired fat oxidation overweight
Conditions
Interventions
3 different dietary polyphenol conditions:
A. EGCG (282mg daily) + resveratrol (200mg daily)
B. EGCG (282mg daily) + resveratrol (200mg daily) + soy isoflavones (48mg
genistein daily)
C. Placebo
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Overweight men and women (BMI>=25kg/m2- 34.9kg/m2), - Aged 20-35 and 35-50 years - Caucasian - Normal fasting glucose (
Exclusion criteria
Exclusion criteria: - Women lactating, pregnant or (post) menopausal - Regular smokers - People with intensive fitness training, eg. athletes (>= 3 per week >= 1 hour training) - Habitual consumption of green tea (more than 1 cup per day) or products containing green tea extract - Total caffeine consumption > 300 mg/day (1 can of cola or 2 cups of regular coffee or 2 cups of black tea or 1 cup of coffee and 1 cup of black tea or other combinations) - Alcohol intake >20 g/day (2 glasses of beer or wine) - Any dietary vitamins or dietary supplements - Diabetes mellitus (defined as FPG >= 7.0 mmol/l and/or 2hPG >= 11.1 mmol/l) - Serious pulmonary, cardiovascular, hepatic or renal disease - History of cardiovascular disease - All other relevant medical disorders that potentially interfere with this trial (e.g. history of gastro-intestinal, liver or thyroid disorders) - Current use of medication interfering with study intervention or interfering with study endpoints/hypotheses (e.g. medication containing caffeine like analgesics, anorectics and analeptics) - Not to be able to understand the study information - Subjects on a special diet or vegetarian - Blood donation 2 months prior to the study and during the study - Participation in other studies - Drug use - Use of anti-coagulant medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the difference in postprandial fat oxidation after the 3 polyphenol conditions | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints, differences in the systemic and local tissue lipolysis, mitochondrial function, oxidative stress, insulin sensitivity and body composition between the various polyphenol supplements are examined. | — |
Countries
Netherlands
Outcome results
None listed