blood vessel disease vascular disease
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All groups: Age>18 years Group A: Patients undergoing elective bypass surgery for coronary arterial disease in which the saphenous vein is used as bypass graft. Group B: Patients receiving an AV-shunt in which a native arm vein is used for creation of the loop and which are having renal failure. Patients undergoing kidney transplantation. Group C: Age/sex-matched patients undergoing surgical procedures in which small vessels are usually ligated or removed. Examples of these surgical procedures include thyroidectomy, inguinal hernia repair, or sarcoma resection.
Exclusion criteria
Exclusion criteria: All groups: Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| During in vitro cell culturing, basic characteristics will be determined and functional tests in high-throughput assays will be performed. The main endpoint will be reproductive capacity of each badge of cells. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters will be cellular adhesion and thrombogenicity for EC and extracellular matrix production for SMC. Besides the cellular in vitro assays, biomarkers for endothelial dysfunction will be measured in plasma. We aim to measure sICAM, sVCAM, vWF and thrombomodulin. Based on the outcomes of above mentioned assays, interindidivual variability will be determined by calculating the coefficient of variation. | — |
Countries
Netherlands
Outcome results
None listed