dysplasia ulcerative colitis
Conditions
Interventions
Screening colonoscopy for ulcerative colitis with different types of
colonoscopes and different endoscopic imaging techniques:
Group A: Chromo-endoscopy, methylene blue 0.1% (HDTV Olympus)
Group B: H
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Signed informed consent form Patients with longstanding ulcerative colitis: at least 8 years after diagnosis or pancolitis and 10 years after diagnosis of left-sided colitis Sex: both males and females Age: above 18 years
Exclusion criteria
Exclusion criteria: Active ulcerative colitis Personal history of colorectal cancer Allergy or intolerance to methylene blue Refusing or incapable to agree with informed consent Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter will be the difference between the three different techniques in the detection of neoplastic lesions in patients with longstanding ulcerative colitis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other end-points are: number of biopsies taken in the different groups, number of detected neoplastic lesions for each technique, number of detected non-neoplastic lesions for each technique, the total number of advanced adenoma defined as adenoma with high grade dysplasia, villous components, intramucosal carcinoma and angio-invasive growth, proportion of patients with low grade adenoma, proportion of patients with high grade adenoma and the duration of total endoscopic procedure time and of endoscopic procedure time during retraction for each technique. | — |
Countries
Netherlands
Outcome results
None listed