brown fat obesity
Conditions
Interventions
In this study the VNS-system is switched off temporarily. This is not part of
the regular VNS treatment. Theoretically this could influence the frequency of
epileptic insults. On the other hand VNS
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects treated with Vagus Nerve Stimulation (VNS) for epilepsy, aged 18-65 years, with a Body Mass Index (BMI)
Exclusion criteria
Exclusion criteria: • Body Mass Index > 28 kg/m2 • Daily epileptic insults. • Subjects that need or needed *Rapid Cycling* VNS to control their frequency of epileptic insults. • Psychological unstable subjects (as judged by the treating neurologist). • subjects with mental retardation (as judged by the treating neurologist). • subjects with severe behaviour disorders (as judged by the treating neurologist). • Pregnant subjects. • Subjects that previously underwent high dose radiation for diagnostic or therapeutic purposes (radiotherapy, high frequency CT-scans). • The use of the following medication is an exclusion criterium; o ß-blockers, o Ketogenic diet • Subjects that recieved high doses of ionising radiation (x-ray or gamma radiation) in their medical history will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is BAT activity in kBq after active VNS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the effect of VNS on energy expenditure, body core temperature, skin surface temperature, skin perfusion and food intake. Other study parameters Other relevant study parameters are medical history, medication, current medical status, age, body weight, weight history, height, sex, thyroid gland function, and UCP-1 and beta3-receptor polymorphisms. | — |
Countries
Netherlands
Outcome results
None listed