PREDICTING THE WIDE-RANGING EFFECTS OF ENHANCING DOPAMINE ON COGNITION

PREDICTING THE WIDE-RANGING EFFECTS OF ENHANCING DOPAMINE ON COGNITION - DOPAMINE AND COGNITION

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38150

Enrollment

100

Registered

2014-01-30

Start date

2014-04-14

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

distractability lack of motivation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers between 18 and 45 years of age

Exclusion criteria

Exclusion criteria: Neuropsychiatric disorders; history of drug abuse; heart problems (see section 3.3 in research protocol (C1) for full list of exclusion criteria)

Design outcomes

Primary

Measure	Time frame
The current study will collect the following primary study parameters Baseline measures: Barratt Simplified Measure of Social Status (Average score) Multidimensional Scale of Perceived Social Support (Average score) Dominance scale (Average score) The Beck Depression Inventory (Average score) The Barratt Impulsiveness Scale (Average score) The BIS/BAS (Behavioural Inhibition Scale/Behavioural Activation (BIS/BAS) Scale (Average score) The Daneman and Carpenter listening span test (Average score) Outcome measures: Social Learning (Beta value for personal learning) Social Learning (Win-stay, lose-shift behaviour) Social Learning (Perseveration) Working memory (Accuracy and reaction time) Motivation x activation reinforcement learning task (Pavlovian bias) Probabilistic reversal learning (Lose-switch, win-stay behaviour) Probabilistic reversal learning (Perseveration) Pavlovian to Instrumental Transfer (Vigour changes upon Pavlovian stimuli) Demand selection task task (Bias towards easy/difficult condition)	—

Measure

Time frame

The current study will collect the following primary study parameters Baseline measures: Barratt Simplified Measure of Social Status (Average score) Multidimensional Scale of Perceived Social Support (Average score) Dominance scale (Average score) The Beck Depression Inventory (Average score) The Barratt Impulsiveness Scale (Average score) The BIS/BAS (Behavioural Inhibition Scale/Behavioural Activation (BIS/BAS) Scale (Average score) The Daneman and Carpenter listening span test (Average score) Outcome measures: Social Learning (Beta value for personal learning) Social Learning (Win-stay, lose-shift behaviour) Social Learning (Perseveration) Working memory (Accuracy and reaction time) Motivation x activation reinforcement learning task (Pavlovian bias) Probabilistic reversal learning (Lose-switch, win-stay behaviour) Probabilistic reversal learning (Perseveration) Pavlovian to Instrumental Transfer (Vigour changes upon Pavlovian stimuli) Demand selection task task (Bias towards easy/difficult condition)

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Secondary

Measure	Time frame
Secondary measures will also be collected for each task (see section 6.1.2 of the research protocol (C1) for further details)	—

Countries

Netherlands

Outcome results