CFTR protein expression in cells from CF patients: correlation with clinical, functional, and inflammatory parameters.

CFTR protein expression in cells from CF patients: correlation with clinical, functional, and inflammatory parameters. - CFTR protein expression in CF patient cells

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38139

Enrollment

234

Registered

2010-08-31

Start date

2011-04-04

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cystic fibrosis

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: All children with cystic fibrosis currently treated in the UMCU

Exclusion criteria

Exclusion criteria: Acute infectious exacerbation for which treatment with intravenous antibiotics is needed.

Design outcomes

Primary

Measure	Time frame
CFTR protein expression in nasal epithelial cells and in immune cells	—

Secondary

Measure	Time frame
Cytokines and chemokines in sputum, blood and bronchoalveolar lavage fluid. Functional testing of lymphocytes, monocytes and granulocytes. Clinical parameters including lung function, chest radiograph score and sputum culture	—

Countries

Netherlands

Outcome results