Betacel dysfunction induced by impaired pancreas anatomy and insulin sensitivity in subjects with heterozygous EXT1 or EXT2 Mutations

Betacel dysfunction induced by impaired pancreas anatomy and insulin sensitivity in subjects with heterozygous EXT1 or EXT2 Mutations - BEEM-2

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38131

Enrollment

Registered

2012-01-26

Start date

2012-05-04

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Caucasian subjects (male/female), aged between 18-65 years of age with heterozygous EXT-1 or EXT-2 mutations as well as unaffected related controls matched for age and gender and subjects wiht known type 2 diabetes mellitus.

Exclusion criteria

Exclusion criteria: claustrophobia, pregnant subjects or female participant at childbearing age not using adequate anticonception, renal dysfunction during screening, exogenous insulin use.

Design outcomes

Primary

Measure	Time frame
-pancreas size (MRI)	—

Secondary

Measure	Time frame
- pancreas permeability (MRI)	—

Countries

Netherlands

Outcome results