Hemodialysis-induced fall in myocardial perfusion: identification of dialysis-specific triggers

Hemodialysis-induced fall in myocardial perfusion: identification of dialysis-specific triggers - Hemodialysis-induced fall in myocardial perfusion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38123

Enrollment

Registered

2011-05-17

Start date

2012-06-07

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac perfusion

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult (age >=18 years) hemodialysis (HD) patients who have been treated with HD for at least three months. Patients must have an arterio-venous fistula without recirculation as established by routine Transonic flow measurements. Pre-HD weight at the first dialysis session of the week must be consistently >2 kg above target weight.

Exclusion criteria

Exclusion criteria: 1. The absence of informed consent. 2. Inability to get echocardiographic windows of adequate quality. 3. Left ventricular ejection fraction

Design outcomes

Primary

Measure	Time frame
The primary study parameter is the change in myocardial blood flow by 13N-NH3 PET.	—

Secondary

Measure	Time frame
Secondary study parameters are the development of left ventricular (LV) regional wall motion abnormalities (akinesia/hypokinesia by PET and echocardiography), electrocardiographic (ECG) signs of ischemia, and laboratory parameters indicative of ischemia (cTnT, cTnI) and inflammation (CRP).	—

Countries

Netherlands

Outcome results