sepsis Liver failure (liver transplant patients)
Conditions
Interventions
Injection of two different substances and measuring plasma clearance to
evaluate the functional liver blood flow in all groups of patients.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Inclusion criteria:;o Age 18 years or older.;o Informed consent of the test person or from her/his lawful representative.;o Patients admitted for liver transplant, hemi-hepatectomy for primary or secondary liver malignancy, or sepsis. ;The control group will be recruited from patients admitted for subarachnoid bleeding without liver disease.
Exclusion criteria
Exclusion criteria: • Exclusion criteria:;o No informed consent.;o Allergy for the administered substances, including inborn errors of the *fructose-pathway*.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study objectives; The main study objective is the clinical use of D-sorbitol plasma clearance as a measure of functional liver blood flow. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed