major depression
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Military personnel and civilians referred for surgical procedures under spinal anesthesia whose four grandparents were born in The Netherlands will be included.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: age 58 years old and the use of benzodiazepines shortly before entering the operating theatre.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of HVA, 5-HIAA and MHPG in CSF will be tested for association with a set of single nucleotide polymorphisms (SNPs). The DNA region of interest is the chromosome region that is homologous to the region that was recently found to be linked with MAM levels in vervet monkeys. Once identified, the effect of associated polymorphisms on RNA expression of monoamine genes will be investigated. MAM levels and associated genotypes will be related to specific behavioral traits, as assessed through validated questionnaires. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary parameter, we will measure CSF amino acid concentrations and correlate these quantitatively to candidate genotypes and behavioral traits as assessed with the abovementioned questionnaires. | — |
Countries
Netherlands
Outcome results
None listed