decompensatio cordis heart decompensation heart failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: - Patients diagnosed with heart failure NYHA class II/III - >= 18 years of age - Mentally able/allowed to give informed consent;Controls: - Subjects free of cardiovascular disease and/or cardiovascular medication - >= 18 years of age - Mentally able/allowed to give informed consent
Exclusion criteria
Exclusion criteria: Controls: Cardiovascular disease The use of cardiovascular medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| magnitude of decline in the combined oxygenated hemoglobin (HbO2) and myoglobin (MbO2) signal from the near-infrared spectroscopy during the cold pressor test at rest and during handgrip exercise at 10 and 30% MVC combined with the cold pressor test. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Brachial artery blood flow (using non-invasive ultrasound as a secondary measure of exercise-induced blood flow during handgrip and performance of the cold pressor test) - Mean arterial blood pressure (Nexfin, contra-lateral arm) (to control for potential differences in the blood pressure response between the subsequent tests) - Forearm blood flow using plethysmography (contra-lateral arm) | — |
Countries
Netherlands
Outcome results
None listed