none none
Conditions
Interventions
Participants will inhale vapor obtained from medical grade Cannabis sativa
(Bedrocan) or placebo from a non-transparent polythene bag using a mouthpiece
with a valve, which prevents loss of THC betw
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: A weekly consumption of cannabis (at least 4 joints) for a minimum of 2 years.
Exclusion criteria
Exclusion criteria: History or presence of an Axis 1 psychiatric disorder (DSM-IV; assessed with the use of the Mini International Neuropsychiatric Interview; M.I.N.I: Lecrubier et al., 1997), clinically significant medical disease, use of psychotropic medication, current or previous regular use of other drugs except cannabis, abuse of alcohol (more than 14 units a week). Additionally, consumption of caffeine, chocolate or alcohol 12 h before the experimental session, consumption of nicotine 2 h before the experimental session. Participants are also not allowed to use cannabis within 2 days before the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference between spontaneous eye blink rates of subjects measured before and after intoxication with THC. Groups with varying dosages of THC and the placebo group will be compared in this regard. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary study parameter is the correlation between spontaneous eye blink rates, performance on the Alternate uses task and Remote associates task and mood as indicated on the Affect grid. Additionally, performance on the Global-local and Stop-signal tasks will be measured. The ERN will also be recorded during completion of a flanker task. Groups with varying dosages of THC and the control group will be compared in these aspects. Moreover, in the groups where THC is administered, three visual analogue scales will be used in order to assess the subjective effects of the drug. | — |
Countries
Netherlands
Outcome results
None listed