vertebral artery stenosis
Conditions
Interventions
The trial will compare a combination of vertebral artery stenting and best
medical treatment with best medical treatment alone.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. TIA or non-disabling ischaemic stroke of the posterior circulation 2. symptoms must have occurred in the 180 days preceding randomisation 3. possibility to perform stenting within two weeks after randomisation 4. stenosis of the vertebral artery of 50% or greater, diagnosed by at least two imaging modalities, and presumed to be of atherosclerotic origin and accessible for endovascular treatment 5. score on the modified Rankin scale
Exclusion criteria
Exclusion criteria: 1. potential cause of TIA or minor stroke other than stenosis in a vertebral artery 2. vertebral artery stenosis caused by arterial dissection 3. previous surgical or endovascular treatment of the stenosis 4. life expectancy shorter than three years 5. other serious illness that may confound outcome assessment 6. severe renal impairment, precluding contrast administration 7. history of severe allergic reaction to iodonised contrast agent 8. pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is any stroke, vascular death, or non-fatal myocardial infarction within 30 days after start of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include any stroke or vascular death during follow-up, stroke in the VB territory within 30 days and during follow-up, and the degree of (re)stenosis after one year. | — |
Countries
Netherlands
Outcome results
None listed