Effect of renal sympathetic denervation on renal and overall sympathetic output in patients with therapy resistant hypertension

Effect of renal sympathetic denervation on renal and overall sympathetic output in patients with therapy resistant hypertension - Effect of renal sympathetic denervation on sympathetic nervous activity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37991

Enrollment

Registered

2012-02-01

Start date

2011-06-20

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Therapy resistant hypertension

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients aged 40-70 years receiving RSD for therapy resistant hypertension, defined as daytime ABPM*150/100 mmHg despite the use of 3 or more anti-hypertensive drugs including or with intolerance to a diuretic.;No evidence of secondary hypertension (renal artery stenosis, pheochromocytoma, primary aldosteronism and hyper- or hypothyroidism have to be excluded prior to the intervention). ;Normal renal anatomy, single renal artery bilaterally.;Able to provide informed consent. ;Willingness to participate.

Exclusion criteria

Exclusion criteria: Renal insufficiency (eGFR1 gram/24 hrs.;Pacemaker or ICD device;Atrial fibrillation;Diabetes Mellitus type 1;Unstable weight 3 months prior to inclusion;Pregnancy ;Treatment of DM type 2 with insulin, PPARγ-agonists or SU-dervatives (for clamp experiment only)

Design outcomes

Primary

Measure	Time frame
Primary objectives: To determine predictors of the BP lowering response of RSD by evaluation of: 1. Assessment of sympathetic tone by beat-to-beat analysis 2. Assessment of the effectiveness of RSD by renal MIBG-uptake post-intervention 3. Assesment of medication adherence before and after RSD.	—

Secondary

Measure	Time frame
Secondary objectives: To assess the auxiliary effects of RSD on: 1. Insulin sensitivity 2. Low grade inflammation 3. Central haemodynamics.	—

Countries

Netherlands

Outcome results