Obesitas Obesity and overweight
Conditions
Interventions
Healthy volunteers will compleet 6 test days in total. Every test day another
substance will be infused into the ileum via the nasoileal catheter:
casein (high and low dose), sucrose (high and low do
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Based on medical history and previous examination, no gastrointestinal complaints can be defined. 2) Age between 18 and 55 years. This study will include healthy adult subjects (Male and Female). Women must be taking oral contraceptives Subjects over 55 years have an increased risk for comorbidities, therefore, subjects over 55 years will not be included. 3) BMI between 18 and 29 kg/m2 4) Less then 2 *yes* responses in the SCOFF questionnaire (see appendix F1) 5) Weight stable over at least the last 6 months
Exclusion criteria
Exclusion criteria: 1) History of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. The severity of the disease (major interference with the execution of the experiment or potential influence on the study outcomes) will be decided by the principal investigator. 2) Use of medication, including vitamin supplementation, except oral contraceptives, within 14 days prior to testing 3) Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study 4) Major abdominal surgery interfering with gastrointestinal function (uncomplicated appendectomy, cholecystectomy and hysterectomy allowed, and other surgery upon judgement of the principle investigator) 5) Dieting (medically prescribed, vegetarian, diabetic, macrobiological, biological dynamic) 6) Pregnancy, lactation 7) Excessive alcohol consumption (>20 alcoholic consumptions per week) 8) Smoking 9) Blood donation within 3 months before the study period 10) Self-admitted HIV-positive state 11) Eating disorders detected using the *SCOFF questionnaire* (in Dutch translation) 12) Lactose or Cow milk intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint - Difference in satiation (as measured by VAS) per time points and difference in food intake as measured during an ad libitum meal | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints - Measurements in plasma and/or platelet poor plasma Plasma levels of the gut hormones Cholecystokinin (CCK), Glucagon Like Peptide-1 (GLP-1) and peptide YY (PYY) Other study parameters: - Gastric emptying by using the C13 stable isotope breath test - Small bowel transit time by using lactulose hydrogen breath test - Gallbladder emptying by gallbladder ultrasound | — |
Countries
Netherlands
Outcome results
None listed