FVIII/FIX deficiency haemophilia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Haemophilia A or B • Severe (
Exclusion criteria
Exclusion criteria: • History of inhibitors • No access to standard care since birth (e.g. immigration from other country) • Last Pettersson score more than 2 years before assessment • More than one knee or ankle with a Pettersson score above 3 points • Less than two knees or ankles with a Pettersson score of 0 points • Extensive bleeding in knees or ankles 2/3 weeks before assessment Controls • contraindication for MRI assessment • knee/ankle injuries within 8 weeks prior to MRI * sports participation less than once weekly or more than 3 times weekly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determinant: MRI findings according to the Lundin additive Score. Outcome parameters: Diagnostic study: HJHS score (T=0) Pettersson score (T=0) Prognostic study: delta HJHS score (T=2.5 and T=5 years) delta Pettersson score (T=5 years) | — |
Secondary
| Measure | Time frame |
|---|---|
| The association of MRI with delta HJHS after 2.5 and 5 years' interval will be adjusted for baseline HJHS score, number of joint bleeds during the observation interval, physical activity, and age. The association of MRI with delta Pettersson score after 5 years' interval will be adjusted for baseline Pettersson score, number of joint bleeds during the observation interval, physical activity, and bone age. | — |
Countries
Netherlands
Outcome results
None listed