BRCA mutations and ovarian ageing in normo-ovulatory women

BRCA mutations and ovarian ageing in normo-ovulatory women - BRAVA-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37959

Enrollment

240

Registered

2011-09-23

Start date

2012-01-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ageing of the ovaries ovarian ageing

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Female with an age ranging between 18-45 years Women with predictive genetic testing on BRCA mutation due to family history, or women with a known BRCA mutation carrier status regular menstrual cylce written informed consent

Exclusion criteria

Exclusion criteria: surgical menopause ovarian surgery chemo-or radiation therapy Known human immunodeficiency virus (HIV) infection Known endocrine or autoimmune abnormalities genetic abnormalities, others than a BRCA mutation, associated with primary ovarian insufficiency

Design outcomes

Primary

Measure	Time frame
Ovarian ageing, measured by age specific serum AMH level.	—

Secondary

Measure	Time frame
Reproductive health/outcome, which is measured by: - subfertility - fertility treatment - parity - miscarriage/abortion - life birth (and gender outcome) - pregnancy success rate (number of pregnancies/ amount of life birth)	—

Countries

Netherlands

Outcome results