depressie, apathie, dagelijks functioneren en kwaliteit van leven Blood pressure and cognition
Conditions
Interventions
Patients will be randomized to either continuation (n=200) or discontinuation
(n=200) of antihypertensive treatment. Discontinuation of antihypertensive
medication by patients* own general practitio
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) age >= 75 years, (2) current antihypertensive treatment with a calcium antagonist, beta-blocker, diuretic, ACE-inhibitor, or angiotensin-II-receptor blocker prescribed by their general practitioner for hypertension, (3) a last systolic blood pressure as reported in the chart of the general practitioner
Exclusion criteria
Exclusion criteria: A history of myocardial infarction and/or coronary reperfusion procedures (CABG/PCI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the change in the compound cognitive score between baseline and follow-up at 4 months after randomisation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are the changes in the four separate cognitive domains (executive functioning, cognitive speed, immediate memory, and delayed memory); depressive symptoms, apathy, daily functioning, and quality of life between baseline and follow-up, 4 months after randomisation; and change in cerebral perfusion at MRI scan. | — |
Countries
Netherlands
Outcome results
None listed