n.v.t.: Onderzoek vindt plaats met gezonde mentaal capabele en wilsbekwame participanten. n.a.: Study will be carried out with healthy participants.
Conditions
Interventions
Psychological intervention: The experimental group receives a standardized 8
week mindfulness intervention adopting the mindfulness based cognitive therapy
(MBCT) protocol. The control group enters
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 18 and 40 years old - Only participants who voluntarily signed up to follow a mindfulness training
Exclusion criteria
Exclusion criteria: - Self-reported health problems use that could influence cortisol levels, immune functioning and/or wound healing (e.g. auto-immune diseases, cancer, recent surgery, strokes, diabetes mellitus, peripheral vascular disease) -Self-reported medication use that could influence cortisol levels, immune functioning and/or wound healing (e.g. anti-diuretics, blood pressure regulators, psychotropic medication, anti-inflammatory drugs) - Other factors that may impact on cortisol levels, immune functioning and/or wound healing: self reported recreational drug use, heavy alcohol use (i.e. more than 10 alcoholic beverages per week for women and more than 20 for men), more than 10 units of caffeinated drinks per day - Psychopathological conditions / psychological treatment currently or over the past 6 months / previous psychiatric hospitalization (all self report) - Structural meditation practice (including yoga, tai chi, etc.) - Allergic responses to adhesives, bandages, or tapes, needle or blood phobias
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomes: Wound surface is determined by digital imaging of the wound 3 - 8 days post wound-induction; Reepithalisation is measured by comparing trans-epidermal water loss above the wound with taht above non damaged skin at 3-8 days . | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes/mediators: Cytokines IL-1a, IL-1β IL6, IL8, TNF-β) from wound exudate 3, 6, and 22 hours post wound-induction; Daily cortisol levels (AUC) and cortisol awakening response; Optimism and positive affect. | — |
Countries
Netherlands
Outcome results
None listed