diabetes and cardiovascular disease
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Partricipant in baseline measurement of the CODAM study (MEC99-112)
Exclusion criteria
Exclusion criteria: None, except for limitations that interfere with any of the procedured to obtain informed consent according to the Helsinki declaration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) Development and progression of insulin resistance, glucose intolerance and type 2 diabetes in the CODAM study population. (2) Development and progression of atherosclerosis, vascular dysfunction and CVD in the CODAM study population. Specific outcomes: - International Classification of Diseases version 10 (ICD-10 codes) : E11 (type 2 diabetes) I10-15 (hypertensive disease) I20-25 (ischaemic heart disease) - Subcutaneous and visceral fat - Ectopic fat in the liver - insulin resistance and glucose tolreance status - Measures of arterial structure (including carotid Intima-Media-Thikcness & Ankle-Brachial Index) and function (including arterial stiffness) - Presence of Metabolic Syndrome (according to the most recent defintion of Alberti et al (2009)) | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Mortality (2) Liver enzymes (reflecting progression of NAFLD). (3) Adiposity (BMI, waist-to-hip ratio, waist circumference, skinfold thickness) (4) Gene expression, biomarkers and/or genetic variations; differences between subjects with and whithout (incident) T2DM (5) Gene expression, biomarkers and/or genetic variations;differences between subjects with and whithout (incident) CVD Outcomes of the Maastriccht studie for as far as these are not included in the primary outomes of the CODAM study. The study can be described in term of study endpoints which are based upon on the International Classification of Diseases version 10 (ICD-10 codes) and include: Diabetes, pre-diabetes and the metabolic syndrome - Ectopic fat in the pancreas Cardiovascular Imaging - I42-44; I47-51 Other Forms of Heart Disease - I26 Pulmonary Embolism - I73.9; I79.2 Peripheral Artery Disease - I80.1-3 Deep Venous Thrombosis C: Neurological Diseases - I61; 63; 64 Cerebrovascular Disease - G43 Migraine - F00-01 Dementia - F32 Depression - H90; 93.1 Diseases of the Ear - H25; 28; 35.8; 36; 40; 54 Diseases of the Eye - G99; 63.3 Neuropathy - Cerebral small vessel disease - Cerebral connectivity D: Respiratory Diseases and other co-morbidities - G47.3 Sleep Apnoea - J41; 42; 44 Respiratory Disease E: Lifestyle & Behavioural Studies - M10 Gout - S02; 12; 22; 32; 42; 52; 62; 72; 82; 92 Fractures - T02; 08; 10; 12; 14.2; 93.2 Fractures - M80-82; 84 Osteoporosis - S91 Ulceration of the Foot or Ankle | — |
Countries
Netherlands
Outcome results
None listed