Arthritis Rheumatoid Arthritis
Conditions
Interventions
None listed
Sponsors
Akeso Medical Imaging BV
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. diagnosis of Rheumatoid Arthritis (or artralgia for control group) 2. No significant visual deformations of the hand and fingers 3. Patients between the age of 18 and 90 years 4. Ability to give informed consent
Exclusion criteria
Exclusion criteria: - Recent surgery or operation, in the last three months, on the wrist, hand or fingers - Allergy to gadolinium contrast (only for subgroup) - Metal objects in any organ or joint (only for subgroup) - Claustrofobia (only for subgroup) - Estimated creatinine clearance by MDRD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To collect data to develop a diagnostic model (algorithm) based on the optical transmission measurements performed by the FHP that can predict the joint inflammation level as assessed by currently accepted methods, such as DAS28, ultrasound, MRI, blood tests and questionnaires. - To evaluate in a cross-sectional study (part I) the level of agreement between predictions of disease activity from optical spectral transmission measurements (algorithm) and conventional disease activity measurements in rheumatoid arthritis patients, i.e. ultrasound, magnetic resonance imaging (MRI), physical examination by a physician (number of swollen and tender joints), blood tests and questionnaires. - To evaluate in a longitudinal study (part II) the correlation between (changes in) optical spectral transmission measurements and DAS28 measurements in patients with severe RA in the cross-sectional part during 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the influence of variables on optical transmission measurements: • Erosions and destruction in joints of the hands and wrists • skin temperature and type • wounds • vasodilatative medication • vasoconstrictive diseases like Raynauds disease | — |
Countries
Netherlands
Outcome results
None listed