Connections between the frontal lobe and the basal ganglia: possible biomarkers for dopaminergic deviations

Connections between the frontal lobe and the basal ganglia: possible biomarkers for dopaminergic deviations - Networks of response selection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37920

Enrollment

Registered

2012-09-20

Start date

2012-11-08

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

geen none

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy subjects between age 18-50 years of age.

Exclusion criteria

Exclusion criteria: The following list of exclusion criteria is used: - nonremovable metal objects in head/body - pregnancy - history of closed or open head injury - history of psychiatric illness - history of neurological illness or endocrinological dysfunction - history of epilepsy - occurrence of epilepsy in 1st degree family - use of medication other than anticonceptive or paracetamol - drug or alcohol abuse over a period of six months prior to the experiment - intake of alcohol, caffeine or nicotine containing products within 4 hrs prior to the scanning sessions. - claustrofobia

Design outcomes

Primary

Measure	Time frame
Four different measures reflecting our control over automatic reactions will be obtained during 4 visits: 1. striatal dopime levels inferred from lactate content using 1H-MRS 2. functional MRI activation measurements in several regions of interest (ROI) 3. effect of TMS on frontal cortex on oculomotor control 4. average score per participant on several behavioral tests A correlation analysis will determine whether inferred striatal dopamine levels per participant will correlate with measures 2-4. This outcome indicates whether striatal dopamine levels explain executive functioning and recruitment of areas in circuits involving the basal ganglia. When this is the case, the above measures are likely biomarkers for diseases affecting dopaminergic neurotransmission.	—

Measure

Time frame

Four different measures reflecting our control over automatic reactions will be obtained during 4 visits: 1. striatal dopime levels inferred from lactate content using 1H-MRS 2. functional MRI activation measurements in several regions of interest (ROI) 3. effect of TMS on frontal cortex on oculomotor control 4. average score per participant on several behavioral tests A correlation analysis will determine whether inferred striatal dopamine levels per participant will correlate with measures 2-4. This outcome indicates whether striatal dopamine levels explain executive functioning and recruitment of areas in circuits involving the basal ganglia. When this is the case, the above measures are likely biomarkers for diseases affecting dopaminergic neurotransmission.

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Countries

Netherlands

Outcome results