Enhancement of the sensitivity of a whole-blood interferon gamma assay (Quantiferon TB Gold) for diagnosis of latent tuberculosis infection

Enhancement of the sensitivity of a whole-blood interferon gamma assay (Quantiferon TB Gold) for diagnosis of latent tuberculosis infection - Quantiferon Improvement Pilot Study (QIPS)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37917

Enrollment

Registered

2012-04-25

Start date

2012-04-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

latent tuberculosis infection

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with an inflammatory disease who are or have been previously screened for latent tuberculosis infection (with or without current treatment with a TNF antagonist) negative controls: healthy uninfected individuals positive controls: known latent TB infection or previously treated TB patients

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
In vitro production of interferon gamma (alternatively IP-10 could be used) in a whole-blood test with specific TB antigens, in which test conditions will be varied in order to enhance the sensitivity	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results