CLINICAL PHARMACOKINETICS OF ROPIVACAINE USING LOCAL INFILTRATION ANESTHESIA (LIA) TECHNIQUE IN THE TOTAL KNEE ARTHROPLASTY: A PILOT STUDY

CLINICAL PHARMACOKINETICS OF ROPIVACAINE USING LOCAL INFILTRATION ANESTHESIA (LIA) TECHNIQUE IN THE TOTAL KNEE ARTHROPLASTY: A PILOT STUDY - PHARO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37901

Enrollment

Registered

2012-01-20

Start date

2012-02-16

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty (total knee replacement)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Totaal knee arthroplasty surgery - Age older than 18 years - Willing to participate in the study after consultation and written informed consent after Pre-Operative Screening (POS)

Exclusion criteria

Exclusion criteria: - Known allergy to amide type local anaesthetics or for any other drugs used routinely during this type of surgery - Mentally retarded - Taking opiates or antiemetics (other than used in the protocol and used prior to the POS) - Taking CYP1A2 inhibitors - Taking CYP3A4 inhibitors - Liver failure (ALAT, ASAT, gamma-GT and bilirubin > 3 times upper reference value)- Renal failure (GFR

Design outcomes

Primary

Measure	Time frame
The determination of pharmacokinetic parameters of ropivacaine after LIA in patients with TKA.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results