Is Transcranial Magnetic Stimulation a potential tool for cognitive therapy in Multiple Sclerosis?

Is Transcranial Magnetic Stimulation a potential tool for cognitive therapy in Multiple Sclerosis? - TMS as potential tool for cognitive therapy in MS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37898

Enrollment

Registered

2012-03-29

Start date

2012-05-30

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MS Multiple Sclerosis

Interventions

Repetitive Transcranial Magnetic Stimulation (rTMS) will be used to temporarily (30 minutes) stimulate the dorsolateral prefrontal cortex in patients and in healthy controls.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 18-55 years - Clinically definite MS (based on Poser criteria, 1983) - Need to meet the safety criteria to undergo an MRI examination - Need to meet the safety criteria to undergo transcranial magnetic stimulation

Exclusion criteria

Exclusion criteria: For all participants: - History of drug abuse - Psychiatric disorders - Claustrophobia - Visual impairment - Foreign non MR compatible metal objects in the body - Foreign metal objects in or close to the head - (family)history of epilepsy, seizures - Use of tricyclic anti-depressants, neuroleptic agents, fampridine and other drugs that lower the seizure threshold - Cardiac rhythmic disorders;Additionally for healthy controls: - Neurological disorders;Additionally for patients: - Other neurological disorders besides MS - Relapse or steroid treatment in the month prior to the investigation - High number of cortical lesions (according to Calabrese et al., Journal of Neurology 2008)

Design outcomes

Primary

Measure	Time frame
More insight will be given into the potential role for rTMS in cognitive therapy in MS patients. This will increase our knowledge on this topic and will hopefully give us insights on how to start future interventional longitudinal cognitive rehabilitation studies. The primary study parameters of this study are: 1) Functional connectivity (resting state and task-specific fMRI): How do task-related (N-back task) and resting state functional connectivity patterns, as measured by functional MRI, change in response to high frequency rTMS in MS? 2) Working memory task performance (task-specific fMRI): How does the performance on the N-back task change in response to a single rTMS application?	—

Measure

Time frame

More insight will be given into the potential role for rTMS in cognitive therapy in MS patients. This will increase our knowledge on this topic and will hopefully give us insights on how to start future interventional longitudinal cognitive rehabilitation studies. The primary study parameters of this study are: 1) Functional connectivity (resting state and task-specific fMRI): How do task-related (N-back task) and resting state functional connectivity patterns, as measured by functional MRI, change in response to high frequency rTMS in MS? 2) Working memory task performance (task-specific fMRI): How does the performance on the N-back task change in response to a single rTMS application?

—

Secondary

Measure	Time frame
As a secondary objective, we are interested in functional changes at the metabolic level of rTMS. To learn more about this, we will perform MR-spectroscopy. Also, we would like to establish that plasticity takes place in the motor cortex when our rTMS protocol is applied to this brain area (positive control). The secondary study parameters of this study are: 3) Are there changes in brain metabolites, specifically in Glutamate/Glutamine levels (as detected by MR spectroscopy) in the prefrontal cortex after stimulation with rTMS? 4) Does rTMS of the motor cortex (M1) of MS patients induce synaptic plasticity?	—

Measure

Time frame

As a secondary objective, we are interested in functional changes at the metabolic level of rTMS. To learn more about this, we will perform MR-spectroscopy. Also, we would like to establish that plasticity takes place in the motor cortex when our rTMS protocol is applied to this brain area (positive control). The secondary study parameters of this study are: 3) Are there changes in brain metabolites, specifically in Glutamate/Glutamine levels (as detected by MR spectroscopy) in the prefrontal cortex after stimulation with rTMS? 4) Does rTMS of the motor cortex (M1) of MS patients induce synaptic plasticity?

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)