ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells

ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells - Bregs in AAV

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37886

Enrollment

160

Registered

2012-11-12

Start date

2013-03-13

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autoimmune vessel wall inflammation vasculitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Over 18 years of age. Study population: Diagnosis Granulomatosis with polyangiitis (GPA; Wegener), or Microscopic polyangiitis according to the 1994 Chapel Hill Consensus conference Positive at any time point for PR3- or MPO-ANCA. Since patients can change from inactive to active patients over time, patients can be included at any time point in their disease course.;Control population: Either any person who reports him or her selves as being healthy, does not use any immune modulating medication and wants to donate blood. Or disease controls being diagnosed with Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren Syndrome or Giant Cell Arteriitis, as judged by the principle investigator.

Exclusion criteria

Exclusion criteria: Unable to consent Unable to donate blood

Design outcomes

Primary

Measure	Time frame
The difference of the number/function of the regulatory B cells in patients who relapse versus the patients that do not relapse, the disease controls and with the healthy controls.	—

Countries

Netherlands

Outcome results