FindTrial
Sign In

Complex Regional Pain syndrome: a (focal) small fibre neuropathy possibly related to mutations in voltage-gated sodium channels

Complex Regional Pain syndrome: a (focal) small fibre neuropathy possibly related to mutations in voltage-gated sodium channels - CRPS SFN

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON37879
Enrollment
50
Registered
2012-04-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

painful neuropathy Peripheral neuropathy

Interventions

None listed

Sponsors

Medisch Universitair Ziekenhuis Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria - diagnosis CRPS1 according to IASP criteria - age > 18 years - at least 2 or more symptoms compatible with SFN - normal findings at neurological and EMG examination, besides changes compatible with SFN involvement.

Exclusion criteria

Exclusion criteria: - Exclusion criteria: - symptoms and signs of large fibre involvement at neurological examination - current or previous neurologic abnormalities unrelated to reflex sympathetic dystrophy - presence of Raynaud*s disease - another condition affecting the function of the disease or contra-lateral extremity - abnormal EMG findings - diagnosis CRPSII

Design outcomes

Primary

MeasureTime frame
The presence of mutations in the SCN9A gene.—

Secondary

MeasureTime frame
- The presence of mutations in SCN10A and SCN11A genes. - Genotype to phenotypical findings (at the impairment level like pain and fatigue severity, autonomic deficits, fatigue, and quality of life impact) of CRPS patients having SCN9A mutations versus those who remain with an unknown aetiology.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)