Human short chain fatty acid metabolism and microbiota

Human short chain fatty acid metabolism and microbiota - Human SCFA metabolism

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37878

Enrollment

Registered

2012-04-02

Start date

2012-06-19

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesitas Obesity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing pylorus preserving pancreactico duodenectomy 18

Exclusion criteria

Exclusion criteria: Ileo- or colostomy Parenchymal and/or inflammatory liver disease Steroid hormone medication n-acetyl cystein medication Lactation, pregnancy and planning of pregnancy Inflammatory bowel disease Coagulation disorders Excessive drinking (>20 alcoholic consumptions per week) and/or smoking Inborn errors of metabolism (liver enzyme deficiencies) Use of antibiotics during and 3 months prior to the study Pre-and probiotic use during and 3 months prior to the study

Design outcomes

Primary

Measure	Time frame
The primary study parameter is the plasma concentration of the SCFAs acetic acid, propionic acid and butyric acid in human measured using High Performance Liquid Chromatograpy (HPLC-MS).	—

Secondary

Measure	Time frame
Other study parameters: Duodenal biopsy: SCFA- receptors GPR41 and GPR43, hormones that influence substrate and energy metabolism (GLP-1, PYY), metabolites (FIAF). Liver biopsy: markers for substrate, energy and/or cholesterol metabolism; glucose 6-phosphate, SREBP-1 expression,	—

Countries

Netherlands

Outcome results