Perioperative maintenance of global tissue perfusion and volemic state in abdominal surgery: Nexfin cardiac output and pulse pressure variation versus arterial blood pressure-guided therapy

Perioperative maintenance of global tissue perfusion and volemic state in abdominal surgery: Nexfin cardiac output and pulse pressure variation versus arterial blood pressure-guided therapy - COGUIDE study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37876

Enrollment

275

Registered

2011-09-28

Start date

2012-01-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal surgery bowel surgery

Interventions

Intervention: Hemodynamic guidance based on arterial blood pressure or cardiac output with pulse pressure variation.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective abdominal surgery Age 18-85 years Exptected duration of surgery > 90 minutes Informed consent

Exclusion criteria

Exclusion criteria: Preexisting cardiac arrhythmias Emergency operation ICU patients Body mass index below 20 kg/m2 and above 40 kg/m2. Patients without an invasive arterial line Decompensatio cordis Aortic valve disease Ejection fraction 30 mm Hg, TAPSE

Design outcomes

Primary

Measure	Time frame
Main study endpoints: The primary endpoint is defined as postoperative morbidity based on the incidence of a number of predefined complications until 30 days after surgery. These parameters include, among others, reoperation, infections, rehabilitation and restoration of gastrointestinal function.	—

Secondary

Measure	Time frame
Secondary endpoints include hospital length of stay and microcirculatory perfusion.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)